ChloroquineV1, Main, Exploration, bibRecord, 000641

Metabolic enzyme PDK3 forms a positive feedback loop with transcription factor HSF1 to drive chemoresistance

Identifieur interne : 000641 ( Main/Exploration ); précédent : 000640; suivant : 000642

Metabolic enzyme PDK3 forms a positive feedback loop with transcription factor HSF1 to drive chemoresistance

Source :

Theranostics [ 1838-7640 ] ; 2019.

RBID : PMC:6568185

Abstract

Background & Aims: Dysregulation of metabolism plays an important role in the development and progression of cancers, while the underlying mechanisms remain largely unknown. This study aims to explore the regulation and relevance of glycolysis in chemoresistance of gastric cancer.

Methods: Biochemical differences between chemoresistant and chemosensitive cancer cells were determined by metabolism profiling, microarray gene expression, PCR or western blotting. Cancer cell growth in vitro or in vivo were analyzed by viability, apoptosis and nude mice assay. Immunoprecipation was used to explore the interaction of proteins with other proteins or DNAs.

Results: By metabolic and gene expression profiling, we found that pyruvate dehydrogenase kinase 3 (PDK3) was highly expressed to promote glycolysis in chemoresistant cancer cells. Its genetic or chemical inhibition reverted chemoresistance in vitro and in vivo. It was transcriptionally regulated by transcription factor HSF1 (Heat shock factor 1). Interestingly, PDK3 can localize in the nucleus and interact with HSF1 to disrupt its phosphorylation by GSK3β. Since HSF1 was subjected to FBXW7-catalyzed polyubiquitination in a phosphorylation-dependent manner, PDK3 prevented HSF1 from proteasomal degradation. Thus, metabolic enzyme PDK3 and transcription factor HSF1 forms a positive feedback loop to promote glycolysis. As a result, inhibition of HSF1 impaired enhanced glycolysis and reverted chemoresistance both in vitro and in vivo.

Conclusions: PDK3 forms a positive feedback loop with HSF1 to drive glycolysis in chemoresistance. Targeting this mitonuclear communication may represent a novel approach to overcome chemoresistance.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568185

DOI: 10.7150/thno.31301
PubMed: 31244938
PubMed Central: 6568185

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Metabolic enzyme PDK3 forms a positive feedback loop with transcription factor HSF1 to drive chemoresistance</title>
<author><name sortKey="Xu, Jinye" sort="Xu, Jinye" uniqKey="Xu J" first="Jinye" last="Xu">Jinye Xu</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China;</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shi, Qiqi" sort="Shi, Qiqi" uniqKey="Shi Q" first="Qiqi" last="Shi">Qiqi Shi</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China;</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xu, Wenxia" sort="Xu, Wenxia" uniqKey="Xu W" first="Wenxia" last="Xu">Wenxia Xu</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China;</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhou, Qiyin" sort="Zhou, Qiyin" uniqKey="Zhou Q" first="Qiyin" last="Zhou">Qiyin Zhou</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Medical Oncology, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China;</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Medical Oncology, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shi, Rongkai" sort="Shi, Rongkai" uniqKey="Shi R" first="Rongkai" last="Shi">Rongkai Shi</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China;</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ma, Yanning" sort="Ma, Yanning" uniqKey="Ma Y" first="Yanning" last="Ma">Yanning Ma</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Radiation Oncology, Shunde Hospital, Southern Medical University, China;</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Radiation Oncology, Shunde Hospital, Southern Medical University</wicri:regionArea>
<wicri:noRegion>Southern Medical University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Dingwei" sort="Chen, Dingwei" uniqKey="Chen D" first="Dingwei" last="Chen">Dingwei Chen</name>
<affiliation wicri:level="3"><nlm:aff id="A4">Department of Surgery, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China;</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Surgery, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhu, Liyuan" sort="Zhu, Liyuan" uniqKey="Zhu L" first="Liyuan" last="Zhu">Liyuan Zhu</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China;</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Feng, Lifeng" sort="Feng, Lifeng" uniqKey="Feng L" first="Lifeng" last="Feng">Lifeng Feng</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China;</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cheng, Alfred Sze Lok" sort="Cheng, Alfred Sze Lok" uniqKey="Cheng A" first="Alfred Sze-Lok" last="Cheng">Alfred Sze-Lok Cheng</name>
<affiliation wicri:level="4"><nlm:aff id="A5">School of Biomedical Sciences, The Chinese University of Hong Kong;</nlm:aff>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Morrison, Helen" sort="Morrison, Helen" uniqKey="Morrison H" first="Helen" last="Morrison">Helen Morrison</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Institute of Molecular Cell Biology, Jena University Hospital, Jena, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea>Institute of Molecular Cell Biology, Jena University Hospital, Jena</wicri:regionArea>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Xian" sort="Wang, Xian" uniqKey="Wang X" first="Xian" last="Wang">Xian Wang</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Medical Oncology, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China;</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Medical Oncology, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jin, Hongchuan" sort="Jin, Hongchuan" uniqKey="Jin H" first="Hongchuan" last="Jin">Hongchuan Jin</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China;</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">31244938</idno>
<idno type="pmc">6568185</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568185</idno>
<idno type="RBID">PMC:6568185</idno>
<idno type="doi">10.7150/thno.31301</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000816</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000816</idno>
<idno type="wicri:Area/Pmc/Curation">000816</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000816</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000591</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000591</idno>
<idno type="wicri:Area/Ncbi/Merge">000733</idno>
<idno type="wicri:Area/Ncbi/Curation">000733</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000733</idno>
<idno type="wicri:Area/Main/Merge">000641</idno>
<idno type="wicri:Area/Main/Curation">000641</idno>
<idno type="wicri:Area/Main/Exploration">000641</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Metabolic enzyme PDK3 forms a positive feedback loop with transcription factor HSF1 to drive chemoresistance</title>
<author><name sortKey="Xu, Jinye" sort="Xu, Jinye" uniqKey="Xu J" first="Jinye" last="Xu">Jinye Xu</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China;</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shi, Qiqi" sort="Shi, Qiqi" uniqKey="Shi Q" first="Qiqi" last="Shi">Qiqi Shi</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China;</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xu, Wenxia" sort="Xu, Wenxia" uniqKey="Xu W" first="Wenxia" last="Xu">Wenxia Xu</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China;</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhou, Qiyin" sort="Zhou, Qiyin" uniqKey="Zhou Q" first="Qiyin" last="Zhou">Qiyin Zhou</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Medical Oncology, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China;</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Medical Oncology, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shi, Rongkai" sort="Shi, Rongkai" uniqKey="Shi R" first="Rongkai" last="Shi">Rongkai Shi</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China;</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ma, Yanning" sort="Ma, Yanning" uniqKey="Ma Y" first="Yanning" last="Ma">Yanning Ma</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Radiation Oncology, Shunde Hospital, Southern Medical University, China;</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Radiation Oncology, Shunde Hospital, Southern Medical University</wicri:regionArea>
<wicri:noRegion>Southern Medical University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Dingwei" sort="Chen, Dingwei" uniqKey="Chen D" first="Dingwei" last="Chen">Dingwei Chen</name>
<affiliation wicri:level="3"><nlm:aff id="A4">Department of Surgery, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China;</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Surgery, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhu, Liyuan" sort="Zhu, Liyuan" uniqKey="Zhu L" first="Liyuan" last="Zhu">Liyuan Zhu</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China;</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Feng, Lifeng" sort="Feng, Lifeng" uniqKey="Feng L" first="Lifeng" last="Feng">Lifeng Feng</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China;</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cheng, Alfred Sze Lok" sort="Cheng, Alfred Sze Lok" uniqKey="Cheng A" first="Alfred Sze-Lok" last="Cheng">Alfred Sze-Lok Cheng</name>
<affiliation wicri:level="4"><nlm:aff id="A5">School of Biomedical Sciences, The Chinese University of Hong Kong;</nlm:aff>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Morrison, Helen" sort="Morrison, Helen" uniqKey="Morrison H" first="Helen" last="Morrison">Helen Morrison</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Institute of Molecular Cell Biology, Jena University Hospital, Jena, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea>Institute of Molecular Cell Biology, Jena University Hospital, Jena</wicri:regionArea>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Xian" sort="Wang, Xian" uniqKey="Wang X" first="Xian" last="Wang">Xian Wang</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Medical Oncology, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China;</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Medical Oncology, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jin, Hongchuan" sort="Jin, Hongchuan" uniqKey="Jin H" first="Hongchuan" last="Jin">Hongchuan Jin</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China;</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Theranostics</title>
<idno type="eISSN">1838-7640</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><bold>Background & Aims</bold>
: Dysregulation of metabolism plays an important role in the development and progression of cancers, while the underlying mechanisms remain largely unknown. This study aims to explore the regulation and relevance of glycolysis in chemoresistance of gastric cancer.</p>
<p><bold>Methods:</bold>
 Biochemical differences between chemoresistant and chemosensitive cancer cells were determined by metabolism profiling, microarray gene expression, PCR or western blotting. Cancer cell growth <italic>in vitro</italic>
 or <italic>in vivo</italic>
 were analyzed by viability, apoptosis and nude mice assay. Immunoprecipation was used to explore the interaction of proteins with other proteins or DNAs.</p>
<p><bold>Results</bold>
: By metabolic and gene expression profiling, we found that pyruvate dehydrogenase kinase 3 (PDK3) was highly expressed to promote glycolysis in chemoresistant cancer cells. Its genetic or chemical inhibition reverted chemoresistance <italic>in vitro</italic>
 and <italic>in vivo</italic>
. It was transcriptionally regulated by transcription factor HSF1 (Heat shock factor 1). Interestingly, PDK3 can localize in the nucleus and interact with HSF1 to disrupt its phosphorylation by GSK3β. Since HSF1 was subjected to FBXW7-catalyzed polyubiquitination in a phosphorylation-dependent manner, PDK3 prevented HSF1 from proteasomal degradation. Thus, metabolic enzyme PDK3 and transcription factor HSF1 forms a positive feedback loop to promote glycolysis. As a result, inhibition of HSF1 impaired enhanced glycolysis and reverted chemoresistance both <italic>in vitro</italic>
 and <italic>in vivo</italic>
.</p>
<p><bold>Conclusions</bold>
: PDK3 forms a positive feedback loop with HSF1 to drive glycolysis in chemoresistance. Targeting this mitonuclear communication may represent a novel approach to overcome chemoresistance.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ferreira, Ja" uniqKey="Ferreira J">JA Ferreira</name>
</author>
<author><name sortKey="Peixoto, A" uniqKey="Peixoto A">A Peixoto</name>
</author>
<author><name sortKey="Neves, M" uniqKey="Neves M">M Neves</name>
</author>
<author><name sortKey="Gaiteiro, C" uniqKey="Gaiteiro C">C Gaiteiro</name>
</author>
<author><name sortKey="Reis, Ca" uniqKey="Reis C">CA Reis</name>
</author>
<author><name sortKey="Assaraf, Yg" uniqKey="Assaraf Y">YG Assaraf</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Qian, X" uniqKey="Qian X">X Qian</name>
</author>
<author><name sortKey="Xu, W" uniqKey="Xu W">W Xu</name>
</author>
<author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name>
</author>
<author><name sortKey="Shi, Q" uniqKey="Shi Q">Q Shi</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Weng, Y" uniqKey="Weng Y">Y Weng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name>
</author>
<author><name sortKey="Lam, Ek" uniqKey="Lam E">EK Lam</name>
</author>
<author><name sortKey="Shin, Vy" uniqKey="Shin V">VY Shin</name>
</author>
<author><name sortKey="Cheng, As" uniqKey="Cheng A">AS Cheng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shukla, Sk" uniqKey="Shukla S">SK Shukla</name>
</author>
<author><name sortKey="Purohit, V" uniqKey="Purohit V">V Purohit</name>
</author>
<author><name sortKey="Mehla, K" uniqKey="Mehla K">K Mehla</name>
</author>
<author><name sortKey="Gunda, V" uniqKey="Gunda V">V Gunda</name>
</author>
<author><name sortKey="Chaika, Nv" uniqKey="Chaika N">NV Chaika</name>
</author>
<author><name sortKey="Vernucci, E" uniqKey="Vernucci E">E Vernucci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kanarek, N" uniqKey="Kanarek N">N Kanarek</name>
</author>
<author><name sortKey="Keys, Hr" uniqKey="Keys H">HR Keys</name>
</author>
<author><name sortKey="Cantor, Jr" uniqKey="Cantor J">JR Cantor</name>
</author>
<author><name sortKey="Lewis, Ca" uniqKey="Lewis C">CA Lewis</name>
</author>
<author><name sortKey="Chan, Sh" uniqKey="Chan S">SH Chan</name>
</author>
<author><name sortKey="Kunchok, T" uniqKey="Kunchok T">T Kunchok</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name>
</author>
<author><name sortKey="Butler, Eb" uniqKey="Butler E">EB Butler</name>
</author>
<author><name sortKey="Tan, M" uniqKey="Tan M">M Tan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hanahan, D" uniqKey="Hanahan D">D Hanahan</name>
</author>
<author><name sortKey="Weinberg, Ra" uniqKey="Weinberg R">RA Weinberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pavlova, Nn" uniqKey="Pavlova N">NN Pavlova</name>
</author>
<author><name sortKey="Thompson, Cb" uniqKey="Thompson C">CB Thompson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lincet, H" uniqKey="Lincet H">H Lincet</name>
</author>
<author><name sortKey="Icard, P" uniqKey="Icard P">P Icard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dasgupta, S" uniqKey="Dasgupta S">S Dasgupta</name>
</author>
<author><name sortKey="Rajapakshe, K" uniqKey="Rajapakshe K">K Rajapakshe</name>
</author>
<author><name sortKey="Zhu, B" uniqKey="Zhu B">B Zhu</name>
</author>
<author><name sortKey="Nikolai, Bc" uniqKey="Nikolai B">BC Nikolai</name>
</author>
<author><name sortKey="Yi, P" uniqKey="Yi P">P Yi</name>
</author>
<author><name sortKey="Putluri, N" uniqKey="Putluri N">N Putluri</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Koo, Jh" uniqKey="Koo J">JH Koo</name>
</author>
<author><name sortKey="Guan, Kl" uniqKey="Guan K">KL Guan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schvartzman, Jm" uniqKey="Schvartzman J">JM Schvartzman</name>
</author>
<author><name sortKey="Thompson, Cb" uniqKey="Thompson C">CB Thompson</name>
</author>
<author><name sortKey="Finley, Lws" uniqKey="Finley L">LWS Finley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bhattacharya, B" uniqKey="Bhattacharya B">B Bhattacharya</name>
</author>
<author><name sortKey="Mohd Omar, Mf" uniqKey="Mohd Omar M">MF Mohd Omar</name>
</author>
<author><name sortKey="Soong, R" uniqKey="Soong R">R Soong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lu, C" uniqKey="Lu C">C Lu</name>
</author>
<author><name sortKey="Ward, Ps" uniqKey="Ward P">PS Ward</name>
</author>
<author><name sortKey="Kapoor, Gs" uniqKey="Kapoor G">GS Kapoor</name>
</author>
<author><name sortKey="Rohle, D" uniqKey="Rohle D">D Rohle</name>
</author>
<author><name sortKey="Turcan, S" uniqKey="Turcan S">S Turcan</name>
</author>
<author><name sortKey="Abdel Wahab, O" uniqKey="Abdel Wahab O">O Abdel-Wahab</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lo Re, O" uniqKey="Lo Re O">O Lo Re</name>
</author>
<author><name sortKey="Douet, J" uniqKey="Douet J">J Douet</name>
</author>
<author><name sortKey="Buschbeck, M" uniqKey="Buschbeck M">M Buschbeck</name>
</author>
<author><name sortKey="Fusilli, C" uniqKey="Fusilli C">C Fusilli</name>
</author>
<author><name sortKey="Pazienza, V" uniqKey="Pazienza V">V Pazienza</name>
</author>
<author><name sortKey="Panebianco, C" uniqKey="Panebianco C">C Panebianco</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, W" uniqKey="Xu W">W Xu</name>
</author>
<author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name>
</author>
<author><name sortKey="Chen, Q" uniqKey="Chen Q">Q Chen</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Ni, P" uniqKey="Ni P">P Ni</name>
</author>
<author><name sortKey="Wu, X" uniqKey="Wu X">X Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Westerheide, Sd" uniqKey="Westerheide S">SD Westerheide</name>
</author>
<author><name sortKey="Anckar, J" uniqKey="Anckar J">J Anckar</name>
</author>
<author><name sortKey="Stevens, Sm Jr" uniqKey="Stevens S">SM Jr Stevens</name>
</author>
<author><name sortKey="Sistonen, L" uniqKey="Sistonen L">L Sistonen</name>
</author>
<author><name sortKey="Morimoto, Ri" uniqKey="Morimoto R">RI Morimoto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sauer, M" uniqKey="Sauer M">M Sauer</name>
</author>
<author><name sortKey="Schuldner, M" uniqKey="Schuldner M">M Schuldner</name>
</author>
<author><name sortKey="Hoffmann, N" uniqKey="Hoffmann N">N Hoffmann</name>
</author>
<author><name sortKey="Cetintas, A" uniqKey="Cetintas A">A Cetintas</name>
</author>
<author><name sortKey="Reiners, Ks" uniqKey="Reiners K">KS Reiners</name>
</author>
<author><name sortKey="Shatnyeva, O" uniqKey="Shatnyeva O">O Shatnyeva</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Song, P" uniqKey="Song P">P Song</name>
</author>
<author><name sortKey="Jiang, T" uniqKey="Jiang T">T Jiang</name>
</author>
<author><name sortKey="Dai, D" uniqKey="Dai D">D Dai</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Sun, J" uniqKey="Sun J">J Sun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name>
</author>
<author><name sortKey="Zhou, W" uniqKey="Zhou W">W Zhou</name>
</author>
<author><name sortKey="Yang, F" uniqKey="Yang F">F Yang</name>
</author>
<author><name sortKey="Chen, G" uniqKey="Chen G">G Chen</name>
</author>
<author><name sortKey="Li, H" uniqKey="Li H">H Li</name>
</author>
<author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hung, Sc" uniqKey="Hung S">SC Hung</name>
</author>
<author><name sortKey="Pochampally, Rr" uniqKey="Pochampally R">RR Pochampally</name>
</author>
<author><name sortKey="Chen, Sc" uniqKey="Chen S">SC Chen</name>
</author>
<author><name sortKey="Hsu, Sc" uniqKey="Hsu S">SC Hsu</name>
</author>
<author><name sortKey="Prockop, Dj" uniqKey="Prockop D">DJ Prockop</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Qiu, Y" uniqKey="Qiu Y">Y Qiu</name>
</author>
<author><name sortKey="Cai, G" uniqKey="Cai G">G Cai</name>
</author>
<author><name sortKey="Su, M" uniqKey="Su M">M Su</name>
</author>
<author><name sortKey="Chen, T" uniqKey="Chen T">T Chen</name>
</author>
<author><name sortKey="Zheng, X" uniqKey="Zheng X">X Zheng</name>
</author>
<author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhou, Q" uniqKey="Zhou Q">Q Zhou</name>
</author>
<author><name sortKey="Li, H" uniqKey="Li H">H Li</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Tan, M" uniqKey="Tan M">M Tan</name>
</author>
<author><name sortKey="Fan, S" uniqKey="Fan S">S Fan</name>
</author>
<author><name sortKey="Cao, C" uniqKey="Cao C">C Cao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bonnet, S" uniqKey="Bonnet S">S Bonnet</name>
</author>
<author><name sortKey="Archer, Sl" uniqKey="Archer S">SL Archer</name>
</author>
<author><name sortKey="Allalunis Turner, J" uniqKey="Allalunis Turner J">J Allalunis-Turner</name>
</author>
<author><name sortKey="Haromy, A" uniqKey="Haromy A">A Haromy</name>
</author>
<author><name sortKey="Beaulieu, C" uniqKey="Beaulieu C">C Beaulieu</name>
</author>
<author><name sortKey="Thompson, R" uniqKey="Thompson R">R Thompson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Subramanian, A" uniqKey="Subramanian A">A Subramanian</name>
</author>
<author><name sortKey="Tamayo, P" uniqKey="Tamayo P">P Tamayo</name>
</author>
<author><name sortKey="Mootha, Vk" uniqKey="Mootha V">VK Mootha</name>
</author>
<author><name sortKey="Mukherjee, S" uniqKey="Mukherjee S">S Mukherjee</name>
</author>
<author><name sortKey="Ebert, Bl" uniqKey="Ebert B">BL Ebert</name>
</author>
<author><name sortKey="Gillette, Ma" uniqKey="Gillette M">MA Gillette</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lu, Cw" uniqKey="Lu C">CW Lu</name>
</author>
<author><name sortKey="Lin, Sc" uniqKey="Lin S">SC Lin</name>
</author>
<author><name sortKey="Chen, Kf" uniqKey="Chen K">KF Chen</name>
</author>
<author><name sortKey="Lai, Yy" uniqKey="Lai Y">YY Lai</name>
</author>
<author><name sortKey="Tsai, Sj" uniqKey="Tsai S">SJ Tsai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Briones Orta, Ma" uniqKey="Briones Orta M">MA Briones-Orta</name>
</author>
<author><name sortKey="Avendano Vazquez, Se" uniqKey="Avendano Vazquez S">SE Avendano-Vazquez</name>
</author>
<author><name sortKey="Ivette Aparicio Bautista, D" uniqKey="Ivette Aparicio Bautista D">D Ivette Aparicio-Bautista</name>
</author>
<author><name sortKey="Coombes, Jd" uniqKey="Coombes J">JD Coombes</name>
</author>
<author><name sortKey="Weber, Gf" uniqKey="Weber G">GF Weber</name>
</author>
<author><name sortKey="Syn, Wk" uniqKey="Syn W">WK Syn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="He, H" uniqKey="He H">H He</name>
</author>
<author><name sortKey="Yu, L" uniqKey="Yu L">L Yu</name>
</author>
<author><name sortKey="Xia, Hh" uniqKey="Xia H">HH Xia</name>
</author>
<author><name sortKey="Lin, Mc" uniqKey="Lin M">MC Lin</name>
</author>
<author><name sortKey="Gu, Q" uniqKey="Gu Q">Q Gu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Santagata, S" uniqKey="Santagata S">S Santagata</name>
</author>
<author><name sortKey="Mendillo, Ml" uniqKey="Mendillo M">ML Mendillo</name>
</author>
<author><name sortKey="Tang, Yc" uniqKey="Tang Y">YC Tang</name>
</author>
<author><name sortKey="Subramanian, A" uniqKey="Subramanian A">A Subramanian</name>
</author>
<author><name sortKey="Perley, Cc" uniqKey="Perley C">CC Perley</name>
</author>
<author><name sortKey="Roche, Sp" uniqKey="Roche S">SP Roche</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Blagosklonny, Mv" uniqKey="Blagosklonny M">MV Blagosklonny</name>
</author>
<author><name sortKey="An, Wg" uniqKey="An W">WG An</name>
</author>
<author><name sortKey="Melillo, G" uniqKey="Melillo G">G Melillo</name>
</author>
<author><name sortKey="Nguyen, P" uniqKey="Nguyen P">P Nguyen</name>
</author>
<author><name sortKey="Trepel, Jb" uniqKey="Trepel J">JB Trepel</name>
</author>
<author><name sortKey="Neckers, Lm" uniqKey="Neckers L">LM Neckers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Yj" uniqKey="Lee Y">YJ Lee</name>
</author>
<author><name sortKey="Kim, Eh" uniqKey="Kim E">EH Kim</name>
</author>
<author><name sortKey="Lee, Js" uniqKey="Lee J">JS Lee</name>
</author>
<author><name sortKey="Jeoung, D" uniqKey="Jeoung D">D Jeoung</name>
</author>
<author><name sortKey="Bae, S" uniqKey="Bae S">S Bae</name>
</author>
<author><name sortKey="Kwon, Sh" uniqKey="Kwon S">SH Kwon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kourtis, N" uniqKey="Kourtis N">N Kourtis</name>
</author>
<author><name sortKey="Moubarak, Rs" uniqKey="Moubarak R">RS Moubarak</name>
</author>
<author><name sortKey="Aranda Orgilles, B" uniqKey="Aranda Orgilles B">B Aranda-Orgilles</name>
</author>
<author><name sortKey="Lui, K" uniqKey="Lui K">K Lui</name>
</author>
<author><name sortKey="Aydin, It" uniqKey="Aydin I">IT Aydin</name>
</author>
<author><name sortKey="Trimarchi, T" uniqKey="Trimarchi T">T Trimarchi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ohnishi, K" uniqKey="Ohnishi K">K Ohnishi</name>
</author>
<author><name sortKey="Takahashi, A" uniqKey="Takahashi A">A Takahashi</name>
</author>
<author><name sortKey="Yokota, S" uniqKey="Yokota S">S Yokota</name>
</author>
<author><name sortKey="Ohnishi, T" uniqKey="Ohnishi T">T Ohnishi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sitarz, R" uniqKey="Sitarz R">R Sitarz</name>
</author>
<author><name sortKey="Skierucha, M" uniqKey="Skierucha M">M Skierucha</name>
</author>
<author><name sortKey="Mielko, J" uniqKey="Mielko J">J Mielko</name>
</author>
<author><name sortKey="Offerhaus, Gja" uniqKey="Offerhaus G">GJA Offerhaus</name>
</author>
<author><name sortKey="Maciejewski, R" uniqKey="Maciejewski R">R Maciejewski</name>
</author>
<author><name sortKey="Polkowski, Wp" uniqKey="Polkowski W">WP Polkowski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kamangar, F" uniqKey="Kamangar F">F Kamangar</name>
</author>
<author><name sortKey="Dores, Gm" uniqKey="Dores G">GM Dores</name>
</author>
<author><name sortKey="Anderson, Wf" uniqKey="Anderson W">WF Anderson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcfate, T" uniqKey="Mcfate T">T McFate</name>
</author>
<author><name sortKey="Mohyeldin, A" uniqKey="Mohyeldin A">A Mohyeldin</name>
</author>
<author><name sortKey="Lu, H" uniqKey="Lu H">H Lu</name>
</author>
<author><name sortKey="Thakar, J" uniqKey="Thakar J">J Thakar</name>
</author>
<author><name sortKey="Henriques, J" uniqKey="Henriques J">J Henriques</name>
</author>
<author><name sortKey="Halim, Nd" uniqKey="Halim N">ND Halim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sutendra, G" uniqKey="Sutendra G">G Sutendra</name>
</author>
<author><name sortKey="Michelakis, Ed" uniqKey="Michelakis E">ED Michelakis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lu, Cw" uniqKey="Lu C">CW Lu</name>
</author>
<author><name sortKey="Lin, Sc" uniqKey="Lin S">SC Lin</name>
</author>
<author><name sortKey="Chien, Cw" uniqKey="Chien C">CW Chien</name>
</author>
<author><name sortKey="Lin, Sc" uniqKey="Lin S">SC Lin</name>
</author>
<author><name sortKey="Lee, Ct" uniqKey="Lee C">CT Lee</name>
</author>
<author><name sortKey="Lin, Bw" uniqKey="Lin B">BW Lin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ma, X" uniqKey="Ma X">X Ma</name>
</author>
<author><name sortKey="Xu, L" uniqKey="Xu L">L Xu</name>
</author>
<author><name sortKey="Alberobello, At" uniqKey="Alberobello A">AT Alberobello</name>
</author>
<author><name sortKey="Gavrilova, O" uniqKey="Gavrilova O">O Gavrilova</name>
</author>
<author><name sortKey="Bagattin, A" uniqKey="Bagattin A">A Bagattin</name>
</author>
<author><name sortKey="Skarulis, M" uniqKey="Skarulis M">M Skarulis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name>
</author>
<author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name>
</author>
<author><name sortKey="Liu, Z" uniqKey="Liu Z">Z Liu</name>
</author>
<author><name sortKey="Ding, Y" uniqKey="Ding Y">Y Ding</name>
</author>
<author><name sortKey="Ledoux, Sp" uniqKey="Ledoux S">SP Ledoux</name>
</author>
<author><name sortKey="Wilson, Gl" uniqKey="Wilson G">GL Wilson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jeoung, Nh" uniqKey="Jeoung N">NH Jeoung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seki, Sm" uniqKey="Seki S">SM Seki</name>
</author>
<author><name sortKey="Gaultier, A" uniqKey="Gaultier A">A Gaultier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aberle, H" uniqKey="Aberle H">H Aberle</name>
</author>
<author><name sortKey="Bauer, A" uniqKey="Bauer A">A Bauer</name>
</author>
<author><name sortKey="Stappert, J" uniqKey="Stappert J">J Stappert</name>
</author>
<author><name sortKey="Kispert, A" uniqKey="Kispert A">A Kispert</name>
</author>
<author><name sortKey="Kemler, R" uniqKey="Kemler R">R Kemler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Calabretta, S" uniqKey="Calabretta S">S Calabretta</name>
</author>
<author><name sortKey="Bielli, P" uniqKey="Bielli P">P Bielli</name>
</author>
<author><name sortKey="Passacantilli, I" uniqKey="Passacantilli I">I Passacantilli</name>
</author>
<author><name sortKey="Pilozzi, E" uniqKey="Pilozzi E">E Pilozzi</name>
</author>
<author><name sortKey="Fendrich, V" uniqKey="Fendrich V">V Fendrich</name>
</author>
<author><name sortKey="Capurso, G" uniqKey="Capurso G">G Capurso</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Luo, W" uniqKey="Luo W">W Luo</name>
</author>
<author><name sortKey="Hu, H" uniqKey="Hu H">H Hu</name>
</author>
<author><name sortKey="Chang, R" uniqKey="Chang R">R Chang</name>
</author>
<author><name sortKey="Zhong, J" uniqKey="Zhong J">J Zhong</name>
</author>
<author><name sortKey="Knabel, M" uniqKey="Knabel M">M Knabel</name>
</author>
<author><name sortKey="O Meally, R" uniqKey="O Meally R">R O'Meally</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sutendra, G" uniqKey="Sutendra G">G Sutendra</name>
</author>
<author><name sortKey="Kinnaird, A" uniqKey="Kinnaird A">A Kinnaird</name>
</author>
<author><name sortKey="Dromparis, P" uniqKey="Dromparis P">P Dromparis</name>
</author>
<author><name sortKey="Paulin, R" uniqKey="Paulin R">R Paulin</name>
</author>
<author><name sortKey="Stenson, Th" uniqKey="Stenson T">TH Stenson</name>
</author>
<author><name sortKey="Haromy, A" uniqKey="Haromy A">A Haromy</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Hong Kong</li>
<li>République populaire de Chine</li>
</country>
<region><li>Zhejiang</li>
</region>
<settlement><li>Hangzhou</li>
<li>Sha Tin</li>
</settlement>
<orgName><li>Université chinoise de Hong Kong</li>
</orgName>
</list>
<tree><country name="République populaire de Chine"><region name="Zhejiang"><name sortKey="Xu, Jinye" sort="Xu, Jinye" uniqKey="Xu J" first="Jinye" last="Xu">Jinye Xu</name>
</region>
<name sortKey="Chen, Dingwei" sort="Chen, Dingwei" uniqKey="Chen D" first="Dingwei" last="Chen">Dingwei Chen</name>
<name sortKey="Feng, Lifeng" sort="Feng, Lifeng" uniqKey="Feng L" first="Lifeng" last="Feng">Lifeng Feng</name>
<name sortKey="Jin, Hongchuan" sort="Jin, Hongchuan" uniqKey="Jin H" first="Hongchuan" last="Jin">Hongchuan Jin</name>
<name sortKey="Ma, Yanning" sort="Ma, Yanning" uniqKey="Ma Y" first="Yanning" last="Ma">Yanning Ma</name>
<name sortKey="Shi, Qiqi" sort="Shi, Qiqi" uniqKey="Shi Q" first="Qiqi" last="Shi">Qiqi Shi</name>
<name sortKey="Shi, Rongkai" sort="Shi, Rongkai" uniqKey="Shi R" first="Rongkai" last="Shi">Rongkai Shi</name>
<name sortKey="Wang, Xian" sort="Wang, Xian" uniqKey="Wang X" first="Xian" last="Wang">Xian Wang</name>
<name sortKey="Xu, Wenxia" sort="Xu, Wenxia" uniqKey="Xu W" first="Wenxia" last="Xu">Wenxia Xu</name>
<name sortKey="Zhou, Qiyin" sort="Zhou, Qiyin" uniqKey="Zhou Q" first="Qiyin" last="Zhou">Qiyin Zhou</name>
<name sortKey="Zhu, Liyuan" sort="Zhu, Liyuan" uniqKey="Zhu L" first="Liyuan" last="Zhu">Liyuan Zhu</name>
</country>
<country name="Hong Kong"><noRegion><name sortKey="Cheng, Alfred Sze Lok" sort="Cheng, Alfred Sze Lok" uniqKey="Cheng A" first="Alfred Sze-Lok" last="Cheng">Alfred Sze-Lok Cheng</name>
</noRegion>
</country>
<country name="Allemagne"><noRegion><name sortKey="Morrison, Helen" sort="Morrison, Helen" uniqKey="Morrison H" first="Helen" last="Morrison">Helen Morrison</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000641 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000641 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:6568185
   |texte=   Metabolic enzyme PDK3 forms a positive feedback loop with transcription factor HSF1 to drive chemoresistance
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:31244938" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a ChloroquineV1

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

Serveur d'exploration Chloroquine

Metabolic enzyme PDK3 forms a positive feedback loop with transcription factor HSF1 to drive chemoresistance

Metabolic enzyme PDK3 forms a positive feedback loop with transcription factor HSF1 to drive chemoresistance

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.